About three years ago, a team of researchers at the University of Washington created a game called FoldIt to allow gamers to contribute to scientific research by playing with the shape and structure of proteins. Why proteins? Well, there are more than 100,000 kinds of protein in the human body, and understanding the structure and makeup of these proteins is key to understanding how they work and as well as to designing drugs that target them.

As proteins are found in the majority of diseases we suffer from, they are also key to developing cures, and so FoldIt enables gamers to design new proteins and fold known proteins into their most workable forms in an effort to contribute to disease prevention.

According to FoldIt’s website, “Foldit attempts to predict the structure of a protein by taking advantage of humans’ puzzle-solving intuitions and having people play competitively to fold the best proteins”.

And last week, FoldIt became more than just a cool idea, or an exercise for scientifically-minded gamers. Scientists have been attempting to decipher a protein called “retroviral protease” for over 15 years, as the protease is one of the key proteins that allows HIV to multiply and replicate itself in living cells. Using FoldIt, gamers were able to identify the structure of the protein — within a matter of 10 days.

With the structure of retroviral protease unlocked, scientists can now begin taking the necessary steps to build a drug that could significantly slow the speed at which HIV develops. The findings were initially published in a Nature article, which readers can find here.

“Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein”, the University of Washington research team said in its findings. “Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs”.

In this MSNBC report, the gamers describe the way in which they were able to work together cooperatively to solve a puzzle that has confounded scientists for more than a decade. And what’s so cool is that, while some of the most important progress in the game was made by those with biomedical academic backgrounds, the majority of active players playing with FoldIt did not have this kind of scientific background. Many of them were just average gamers like you and I.

“The monkey-virus puzzle solution demonstrates that Foldit and other science-oriented video games could be used to address a wide range of other scientific challenges — ranging from drug development to genetic engineering for future biofuels”, Firas Khatib, a biochemist at the University of Washington told MSNBC. “My hope is that scientists will see this research and give us more of those cases”.

What a remarkable win for the non-shallow end of gamification. We hear so much about how game layers are being added to consumer tech products to encourage engagement and interaction with products and apps, but with FoldIt, we have a real example of how gamification can help solve some of the trickiest of scientific problems and help make the world a better place.

Way to go, gamers.

Credits: http://techcrunch.com/2011/10/01/one-up-gamers-help-scientists-solve-molecular-puzzle-that-could-lead-to-aids-vaccine/

My train is about to move, yes its started moving slowly…suddenly I see two ladies with their children are trying to get into moving train.. and a man inside train is telling .. “Come.. come fast and get in”…. All other people are watching them, and they have no idea what is going to happen…. Some people are shouting “leave this train, and go by next one”… these ladies are not hearing to them and they are running fast to catch the train… and in between one of their kid fell on platform… at that time…. one tea boy stopped them and shouted at those ladies… “hey..are you going to kill your children…don’t you have brains?”   then few others joined and blocked them to get into train…  frustrated people scold them, and make them realize…

These people have no brains… its for sure…even though they are hearing about may accidents happening in platform..while jumping from running train and getting into moving train, many of them become handicapped…. and few of them lost their son, sisters and husbands… still they don’t think about it…yes they need “more” BRAINS… Its sure that tomorrow again they will try to jump into moving train….

This is the text of the Commencement address by Steve Jobs, CEO of Apple Computer and of Pixar Animation Studios, delivered on June 12, 2005.

I am honored to be with you today at your commencement from one of the finest universities in the world. I never graduated from college. Truth be told, this is the closest I’ve ever gotten to a college graduation. Today I want to tell you three stories from my life. That’s it. No big deal. Just three stories.

The first story is about connecting the dots.

I dropped out of Reed College after the first 6 months, but then stayed around as a drop-in for another 18 months or so before I really quit. So why did I drop out?

It started before I was born. My biological mother was a young, unwed college graduate student, and she decided to put me up for adoption. She felt very strongly that I should be adopted by college graduates, so everything was all set for me to be adopted at birth by a lawyer and his wife. Except that when I popped out they decided at the last minute that they really wanted a girl. So my parents, who were on a waiting list, got a call in the middle of the night asking: “We have an unexpected baby boy; do you want him?” They said: “Of course.” My biological mother later found out that my mother had never graduated from college and that my father had never graduated from high school. She refused to sign the final adoption papers. She only relented a few months later when my parents promised that I would someday go to college.

And 17 years later I did go to college. But I naively chose a college that was almost as expensive as Stanford, and all of my working-class parents’ savings were being spent on my college tuition. After six months, I couldn’t see the value in it. I had no idea what I wanted to do with my life and no idea how college was going to help me figure it out. And here I was spending all of the money my parents had saved their entire life. So I decided to drop out and trust that it would all work out OK. It was pretty scary at the time, but looking back it was one of the best decisions I ever made. The minute I dropped out I could stop taking the required classes that didn’t interest me, and begin dropping in on the ones that looked interesting.

It wasn’t all romantic. I didn’t have a dorm room, so I slept on the floor in friends’ rooms, I returned coke bottles for the 5¢ deposits to buy food with, and I would walk the 7 miles across town every Sunday night to get one good meal a week at the Hare Krishna temple. I loved it. And much of what I stumbled into by following my curiosity and intuition turned out to be priceless later on. Let me give you one example:

Reed College at that time offered perhaps the best calligraphy instruction in the country. Throughout the campus every poster, every label on every drawer, was beautifully hand calligraphed. Because I had dropped out and didn’t have to take the normal classes, I decided to take a calligraphy class to learn how to do this. I learned about serif and san serif typefaces, about varying the amount of space between different letter combinations, about what makes great typography great. It was beautiful, historical, artistically subtle in a way that science can’t capture, and I found it fascinating.

None of this had even a hope of any practical application in my life. But ten years later, when we were designing the first Macintosh computer, it all came back to me. And we designed it all into the Mac. It was the first computer with beautiful typography. If I had never dropped in on that single course in college, the Mac would have never had multiple typefaces or proportionally spaced fonts. And since Windows just copied the Mac, it’s likely that no personal computer would have them. If I had never dropped out, I would have never dropped in on this calligraphy class, and personal computers might not have the wonderful typography that they do. Of course it was impossible to connect the dots looking forward when I was in college. But it was very, very clear looking backwards ten years later.

Again, you can’t connect the dots looking forward; you can only connect them looking backwards. So you have to trust that the dots will somehow connect in your future. You have to trust in something — your gut, destiny, life, karma, whatever. This approach has never let me down, and it has made all the difference in my life.

My second story is about love and loss.

I was lucky — I found what I loved to do early in life. Woz and I started Apple in my parents garage when I was 20. We worked hard, and in 10 years Apple had grown from just the two of us in a garage into a $2 billion company with over 4000 employees. We had just released our finest creation — the Macintosh — a year earlier, and I had just turned 30. And then I got fired. How can you get fired from a company you started? Well, as Apple grew we hired someone who I thought was very talented to run the company with me, and for the first year or so things went well. But then our visions of the future began to diverge and eventually we had a falling out. When we did, our Board of Directors sided with him. So at 30 I was out. And very publicly out. What had been the focus of my entire adult life was gone, and it was devastating.

I really didn’t know what to do for a few months. I felt that I had let the previous generation of entrepreneurs down – that I had dropped the baton as it was being passed to me. I met with David Packard and Bob Noyce and tried to apologize for screwing up so badly. I was a very public failure, and I even thought about running away from the valley. But something slowly began to dawn on me — I still loved what I did. The turn of events at Apple had not changed that one bit. I had been rejected, but I was still in love. And so I decided to start over.

I didn’t see it then, but it turned out that getting fired from Apple was the best thing that could have ever happened to me. The heaviness of being successful was replaced by the lightness of being a beginner again, less sure about everything. It freed me to enter one of the most creative periods of my life.

During the next five years, I started a company named NeXT, another company named Pixar, and fell in love with an amazing woman who would become my wife. Pixar went on to create the worlds first computer animated feature film, Toy Story, and is now the most successful animation studio in the world. In a remarkable turn of events, Apple bought NeXT, I returned to Apple, and the technology we developed at NeXT is at the heart of Apple’s current renaissance. And Laurene and I have a wonderful family together.

I’m pretty sure none of this would have happened if I hadn’t been fired from Apple. It was awful tasting medicine, but I guess the patient needed it. Sometimes life hits you in the head with a brick. Don’t lose faith. I’m convinced that the only thing that kept me going was that I loved what I did. You’ve got to find what you love. And that is as true for your work as it is for your lovers. Your work is going to fill a large part of your life, and the only way to be truly satisfied is to do what you believe is great work. And the only way to do great work is to love what you do. If you haven’t found it yet, keep looking. Don’t settle. As with all matters of the heart, you’ll know when you find it. And, like any great relationship, it just gets better and better as the years roll on. So keep looking until you find it. Don’t settle.

My third story is about death.

When I was 17, I read a quote that went something like: “If you live each day as if it was your last, someday you’ll most certainly be right.” It made an impression on me, and since then, for the past 33 years, I have looked in the mirror every morning and asked myself: “If today were the last day of my life, would I want to do what I am about to do today?” And whenever the answer has been “No” for too many days in a row, I know I need to change something.

Remembering that I’ll be dead soon is the most important tool I’ve ever encountered to help me make the big choices in life. Because almost everything — all external expectations, all pride, all fear of embarrassment or failure – these things just fall away in the face of death, leaving only what is truly important. Remembering that you are going to die is the best way I know to avoid the trap of thinking you have something to lose. You are already naked. There is no reason not to follow your heart.

About a year ago I was diagnosed with cancer. I had a scan at 7:30 in the morning, and it clearly showed a tumor on my pancreas. I didn’t even know what a pancreas was. The doctors told me this was almost certainly a type of cancer that is incurable, and that I should expect to live no longer than three to six months. My doctor advised me to go home and get my affairs in order, which is doctor’s code for prepare to die. It means to try to tell your kids everything you thought you’d have the next 10 years to tell them in just a few months. It means to make sure everything is buttoned up so that it will be as easy as possible for your family. It means to say your goodbyes.

I lived with that diagnosis all day. Later that evening I had a biopsy, where they stuck an endoscope down my throat, through my stomach and into my intestines, put a needle into my pancreas and got a few cells from the tumor. I was sedated, but my wife, who was there, told me that when they viewed the cells under a microscope the doctors started crying because it turned out to be a very rare form of pancreatic cancer that is curable with surgery. I had the surgery and I’m fine now.

This was the closest I’ve been to facing death, and I hope it’s the closest I get for a few more decades. Having lived through it, I can now say this to you with a bit more certainty than when death was a useful but purely intellectual concept:

No one wants to die. Even people who want to go to heaven don’t want to die to get there. And yet death is the destination we all share. No one has ever escaped it. And that is as it should be, because Death is very likely the single best invention of Life. It is Life’s change agent. It clears out the old to make way for the new. Right now the new is you, but someday not too long from now, you will gradually become the old and be cleared away. Sorry to be so dramatic, but it is quite true.

Your time is limited, so don’t waste it living someone else’s life. Don’t be trapped by dogma — which is living with the results of other people’s thinking. Don’t let the noise of others’ opinions drown out your own inner voice. And most important, have the courage to follow your heart and intuition. They somehow already know what you truly want to become. Everything else is secondary.

When I was young, there was an amazing publication called The Whole Earth Catalog, which was one of the bibles of my generation. It was created by a fellow named Stewart Brand not far from here in Menlo Park, and he brought it to life with his poetic touch. This was in the late 1960′s, before personal computers and desktop publishing, so it was all made with typewriters, scissors, and polaroid cameras. It was sort of like Google in paperback form, 35 years before Google came along: it was idealistic, and overflowing with neat tools and great notions.

Stewart and his team put out several issues of The Whole Earth Catalog, and then when it had run its course, they put out a final issue. It was the mid-1970s, and I was your age. On the back cover of their final issue was a photograph of an early morning country road, the kind you might find yourself hitchhiking on if you were so adventurous. Beneath it were the words: “Stay Hungry. Stay Foolish.” It was their farewell message as they signed off. Stay Hungry. Stay Foolish. And I have always wished that for myself. And now, as you graduate to begin anew, I wish that for you.

Stay Hungry. Stay Foolish.

Thank you all very much.

Contents from:   http://news.stanford.edu/news/2005/june15/jobs-061505.html

– Hard link is the mirror copy of original file

– Same inode number for both Hard link and the original file

– Even if you delete any of the file, noting will happen to other file

– Hard link is not allowed for directory

– UNIX or Linux does not allow creating hard links across file system boundaries. Follow the URL to know more.

Soft Link:

– Soft link is the symbolic link(just like shortcut in windows) for original file

– Different inode number for soft link and original file

– If you delete the original file, the soft link fails.

– If you delete the soft link file, nothing happen to original file

– Soft link is allowed for directory

If you edit the original file, the same will reflect to both hardlink and softlink files.

To set the java heap size, follow the below steps:

– Stop Tomcat server

– run the following command

export CATALINA_OPTS=”-Xms256m -Xmx512m”

or

export JAVA_OPTS=”-Xms256m -Xmx512m”

– Start Tomcat

You can also use the above variables in your Tomcat startup scripts:

Check the file Tomcat-Home/bin/catalina.sh or catalina.bat , and then restart the Tomcat server

set CATALINA_OPTS=-Xms256m -Xmx512m (For Windows, no “” around the value)

export CATALINA_OPTS=-Xms256m -Xmx512m (For ksh/bash, “” around the value)

setenv CATALINA_OPTS=-Xms256m -Xmx512m (For tcsh/csh, “” around the value)

Hum, rahen ya na rahen kal
Kal yaad aayenge ke ye pal
Pal, ye hain pyar ke pal
Chal, aa mere sang chal
Chal, soche kya
Chhoti si, hai zindagi
Kal, mil jaaye to hogi khush-naseebi

Hum rahen ya na rahen yaad aayenge ye pal

Hum rahen ya na rahen kal
Kal, yaad aayenge ye pal
Pal, ye hain pyar ke pal
Chal, aa mere sang chal
Chal, soche kya
Chhoti si, hai zindagi
Kal, mil jaaye to hogi khush-naseebi

Hum rahen ya na rahen yaad aayenge ye pal

Shaam ka aanchal, odh ke aayee dekho woh raat suhani
Aa likh dein hum dono milke apni ye prem kahani
Hum rahen ya na rahen yaad aayenge ye pal

Aane waali subah jaane rang kya laaye deewanee,
Meri chaahat ko rakh lena jaise koi nishani
Hum rahen ya na rahen yaad aayenge ye pal

Hum rahen ya na rahen kal
Kal, yaad aayenge ye pal
Pal, ye hain pyar ke pal
Chal, aa mere sang chal
Chal, soche kya chhoti si hai zindagi
Kal mil jaaye to hogi khush-naseebi

Hum rahen ya na rahen yaad aayenge ye pal
Hum rahen ya na rahen yaad aayenge ye pal

Yaaron dosti badi hi haseen hai
Yeh na ho to kya phir
Bolo yeh zindagi hai

Koi to ho raazdaar
Begaraj tera ho yaar
Koi to ho raazdaar

Yaaron mohabbat hi to bandagi hai
Yeh na ho to kya phir bolo yeh zindagi hai

Koi to dilbar ho yaar
Jisko tujhse ho Pyaar
Koi to dilbar ho yaar

Teri har ke buraai pe daante woh dost
Gam ki ho dhoop to saaya bane tera woh dost

Naache bhi woh teri khushi main
aree Yaaron dosti badi hi haseen hai

Yeh na ho to kya phir
Bolo yeh zindagi hai
Koi to ho raazdaar
Begaraj tera ho yaar
Koi to ho raazdaar

Tan mann kar tujhpe fida
Mehboob woh
Palkon pe jo rakhe tujhe
Mehboob woh
Jiski vafa tere liye ho

Are Yaaron mohabbat hi to bandagi hai
Yeh na ho to kya phir
Bolo yeh zindgi hai
Koi to dilbar ho yaar
Jisko tujhse ho pyaar
Koi to dilbar ho yaar

Film : Puthiya Mukham
Singer : Shankar Mahadevan
Lyrics: Kaithapram Damodaran Namboothiri
Music : Deepak Dev

Picha vacha naal muthalkku nee ente swantham ente swanthamayi
asha kondu koodu kootti naam ishtam koodi ennum ennum
picha vacha naal muthalkku nee ente swantham ente swanthamayi
asha kondu koodu kootti naam ishtam koodi ennum ennum
picha vacha naal muthalkku nee…..

Veedorungi naadorungi kalpathi therorungi pongalumayi vannu pournami
Veedorungi naadorungi kalpathi therorungi pongalumayi vannu pournami
kayil kuppivalayude melam kaalil padhaswarathinte thaalam
azhakai nee thulumbunnu arikil hridayam kulirunnu

Picha vacha naal muthalkku nee ente swantham ente swanthamayi
asha kondu koodu kootti naam ishtam koodi ennum ennum
picha vacha naal muthalkku nee

na na naa na na na nana nana naaaa na

dhirina dhirina ni dha pa ma ri ma ri pa ni dha sa ni dha ma pa

koolamittu ponpulari kodamanjin thaazhvarayil manjalayil maanju poyi naam
koolamittu ponpulari kodamanjin thaazhvarayil manjalayil maanju pooyi naam
chundil chorum chenthamizh chinthu maaril cherunnu muthamizh chantham
mridhu mounam mayangunnu amruthum theenum kalarunnu

Picha vacha naal muthalkku nee ente swantham ente swanthamayi
asha kondu koodu kootti naam ishtam koodi ennum ennum
picha vacha naal muthalkku nee ente swantham ente swanthamayi
asha kondu koodu kootti naam ishtam koodi ennum ennum
picha vacha naal muthalkku nee

Movie: Neelathamara
Music: Vidyasagar
Year: 2009
Singer: Karthik

Neelathamare punyam choodiyen
dhanyamaam thapasill
neelathamare olam neeti nee
dhyanamaam sarasil
aavani naalil njaan kaniyekum kavadi nee aninju
aathiraravil nin mizhineerin
manjill njaan nananju

venn sooryanakale therilanaye
melle unarum charuthe
kann peeli nirakal ninne uzhiyaan
chinni varavaay snehithe.

neelathamare punyam choodiyen
dhanyamaam thapasill

kunjalla pulkum nallazhake nin
aamukham innezhuthumbol
kunjalla pulkum nallazhake nin
aamukham innezhuthumbol
yen akamaake eerananinju
ninn katha onnu virinju

venn sooryanakale therilanaye
melle unarum charuthe
kann peeli nirakal ninne uzhiyaan
chinni varavaay snehithe.

nin chiriyetho ponnushasayan
chundillulthungi irrunu
nin chiriyetho ponnushasayan
chundillulthungi irrunu
ninn vyetha oro sandhyakalayen
thazhvara thannilalinju

venn sooryanakale therilanaye
melle unarum charuthe
kann peeli nirakal ninne uzhiyaan
chinni varavaay snehithe.

anuraagavilochananai athilere mohithanai
padimele nilkkum chandrano thidukkam(2)
pathinezhin paurnami kaanum azhakellamulloru poovinu
ariyathinnenthe enthe ithalanakkam
puthuminukkam..cherumayakkam..
anuraagavilochananai athilere mohithanai
padimele nilkkum chandrano thidukkam
palanaalai thaazheyirangaan oru thidukkam

ho..kaliyum chiriyum nirayum kanavil
ilaneerozhuki kuliril
thanalum veyilum punarum thodiyil
mizhikal paayunnu kothiyil
kaananullilulla bhayamo
kaanaanereyulla rasamo
onnaivannirunnu veruthe padavil
kaathirippo vingalalle
kaalminno maunamalle
maunam theerillee

anuraagavilochanananai athilere mohithanai
padimele nilkkum chandrano thidukkam
palanaalai thaazheyirangaan oru thidukkam

aahaa aahaa aaa…
aaa…aahaaa. na naaa naa naa..
puzhayum mazhayum thazhukum shilayil
pulakam pathivaai niraye
manassin nadayil viriyaaniniyum
maranno nee neela malare
naanam poothu poothu kozhiye
eenam kettu kettu kazhiye
raavo yaathra poyi thaniye akalee
raakkadambin gandhamode raakkinavin chandamode
veendum cherille

anuraagavilochanananai athilere mohithanai
padimele nilkkum chandrano thidukkam
palanaalai thaazheyirangaan oru thidukkam